研究業績

| 2000〜2017年の研究業績 | 1974〜1999年の研究業績 |
発表論文: 英文和文   著書: 英文、 和文   その他(研究報告等)
【2000年〜2017年の教室業績】 
発表論文 (英文)

    【2017】
  1. Yamazaki Y, Sumikawa K.(2017) Nicotine-induced neuroplasticity counteracts the effect of schizophrenia-linked neuregulin 1 signaling on NMDAR function in the rat hippocampus. Neuropharmacology. 2017; 113; 386-395

  2. 【2016】
  3. Sugita M, Yamazaki Y, Goto JI, Fujiwara H, Aihara T, Mikoshiba K, Fujii S.(2016) Role of postsynaptic inositol 1, 4, 5-trisphosphate receptors in depotentiation in guinea pig hippocampal CA1 neurons. Brain Research. 2016; 1642: 154-162.
  4. Fujii S, Yamazaki Y, Goto J, Fujiwara H, Mikoshiba K.(2016) Prior activation of inositol 1,4,5-trisphosphate receptors suppresses the subsequent induction of long-term potentiation in hippocampal CA1 neurons. Learning Memory. 2016; 23(5): 208-219.
  5. Otsuki N, Homma T, Fujiwara H, Kaneko K, Hozumi Y, Shichiri M, Takashima M, Ito J, Konno T, Kurahashi T, Yoshida Y, Goto K, Fujii S, Fujii J(2016) Trichloroethylene exposure aggravates behavioral abnormalities in mice that are deficient in superoxide dismutase. Regulatory Toxicology and Pharmacology. 2016 Aug(79): 83-90.
  6. Sugisaki E, Fukushima Y, Fujii S, Yamazaki Y, Aihara T.(2016) The effect of coactivation of muscarinic and nicotinic acetylcholine receptors on LTD in the hippocampal CA1 network. Brain Research. 2016; 1649: 44-52

  7. 【2015】
  8. Chida K, Kaneko K, Fujii S, Yamazaki Y.(2015) Activity-dependent modulation of the axonal conduction of action potentials along rat hippocampal mossy fibers. European Journal of Neuroscience. 2015; 41(1): 45-54
  9. Yamazaki Y, Fujii S, Goto JI, Fujiwara H, Mikoshiba K.(2015) Activation of inositol 1,4,5-trisphosphate receptors during preconditioning low-frequency stimulation suppresses subsequent induction of long-term potentiation in hippocampal CA1 neurons. Neuroscience. 2015; 17(311): 195-206
  10. Yamazaki Y, Fujii S.(2015) Extracellular ATP modulates synaptic plasticity induced by activation of metabotropic glutamate receptors in the hippocampus. Biomedical Research. 2015; 36(1): 1-9

  11. 【2014】
  12. Ishibashi M*, Yamazaki Y*, Miledi R, Sumikawa K.(2014) Nicotinic and muscarinic agonists and acetylcholinesterase inhibitors stimulate a common pathway to enhance GluN2B-NMDAR responses. Proc Natl Acad Sci USA 2014;111: 12538-12543 *These authors contributed equally to this work.
  13. Yamazaki Y, Fujiwara H, Kaneko K, Hozumi Y, Xu M, Ikenaka K, Fujii S, Tanaka KF.(2014) Short- and long-term functional plasticity of white matter induced by oligodendrocyte depolarization in the hippocampus. Glia 2014;62: 1299-1312
  14. Fujii S, Tanaka KF, Ikenaka K, Yamazaki Y.(2014) Increased adenosine levels in mice expressing mutant glial fibrillary acidic protein in astrocytes result in failure of induction of LTP reversal (depotentiation) in hippocampal CA1 neurons. Brain Res 2014;1578: 1-13
  15. Yamazaki Y.(2014) Increased adenosine levels caused by astrocyte dysfunction result in enhanced excitability of the hippocampus. Ann Rep Jpn Epi Res Found 2014;25: 1-7
  16. Hendron E, Wang X, Zhou Y, Cai X, Goto J, Mikoshiba K, Baba Y, Kurosaki T, Wang Y, Gill DL(2014) Potent functional uncoupling between STIM1 and Orai1 by dimeric 2- aminodiphenyl borinate analogs. Cell Calcium 2014;56: 482-492

  17. 【2013】
  18. Kondo M, Kitajima T, Fujii S, Tsukada M, Aihara T. (2013) Modulation of synaptic plasticity by the coactivation of spatially distinct synaptic inputs in rat hippocampal CA1 apical dendrites. Brain Res 2013;1526: 1-14
  19. Lee HU, Yamazaki Y, Tanaka KF, Furuya K, Sokabe M, Hida H, Takao K, Miyakawa T, Fujii S, Ikenaka K. (2013) Increased astrocytic ATP release results in enhanced excitability of the hippocampus. Glia 2013;61: 210-224
  20. Li J, Sasaki H, Fujiwara H, Kato H, Kaneko K, Yamazaki Y, Fujii S. (2013) Synaptic plasticity in hippocampal CA1 neurons and learning behavior in transient ischemia-loaded gerbils. Biomed Res 2013;34: 75-85

  21. 【2012】
  22. Suzuki Y, Yamazaki Y, Hozumi Y, Okada M, Tanaka T, Iseki K, Ohta N, Aoyagi M, Fujii S, Goto K.(2012) NMDA receptor-mediated Ca(2+) influx triggers nucleocytoplasmic translocation of diacylglycerol kinase ζ under oxygen-glucose deprivation conditions, an in vitro model of ischemia, in rat hippocampal slices. Histochem Cell Biol. 137(4):499-511.
  23. Yamazaki Y, Fujii S, Aihara T, Mikoshiba K. (2012) Activation of inositol 1, 4, 5-trisphosphate receptors during preconditioning low-frequency stimulation leads to reversal of long-term potentiation in hippocampal CA1 neurons. Neuroscience. 207:1-11.
  24. Yamazaki Y, Fujii S, Goto JI, Sugihara T, Sugita M, Fujiwara H, Kaneko K, Aihara T, Mikoshiba K.(2012) Suppressive effect of preconditioning low-frequency stimulation on subsequent induction of long-term potentiation by high frequency stimulation in hippocampal CA3 neurons. Brain Res. 1449: 15-23
  25. Ishikawa S, Ishikawa H, Shindo T, Yoshida T, Shimoyama Y, Satomi T, Fujii S, Hamamoto Y, Iino M, Fukao A.(2012) Effects of occupational environmental controls and work management on chromosomal damage in dental technicians in Japan. Int J Hyg Environ Health. Mar 14
  26. Lee HU, Yamazaki Y, Tanaka KF, Furuya K, Sokabe M, Hida H, Takao K, Miyakawa T, Fujii S, Ikenaka K.(2012) Increased astrocytic ATP release results in enhanced excitability of the hippocampus. Glia 61: 210-224
  27. Fujiwara H, Ikarashi K, Yamazaki Y, Goto JI, Kaneko K, Sugita M, Kato H, Sasaki H, Inokuchi JI, Furukawa K, Fujii S.(2012) Impairment of hippocampal long-term potentiation and failure of learning in mice treated with D-threo-1-phenyl-2-decanoylamino-3-morpholino-1- propanol. Biomed Res 33: 265-271
  28. Fujiwara H, Sawa K, Takahashi M, Johan L, Tsukada M, Aihara T.(2012) Context and the renewal of conditioned taste aversion: the role of rat dorsal hippocampus examined by electrolytic lesion. Cogn Neurodyn 6: 399-407
  29. Goto JI, Fujii S, Yamazaki Y, Mikoshiba K.(2012) Prior synaptic inputs are engraved on the following synaptic plasticity with inositol 1, 4, 5-trisphosphate receptor activation in hippocampal neurons. Messenger 1: 121-132

  30. 【2011】
  31. Ikarashi K., Fujiwara H., Yamazaki Y., Goto J-I., Kaneko K., Kato H., Fujii S., Sasaki H., Fukumoto S., Furukawa K., Waki H. & Furukawa K. (2011) Impaired hippocampal long-term potentiation and failure of learning in β 1,4-N-acetylgalactosaminyltransferase gene transgenic mice. Glycobiol. 21:1373-1381.
  32. Yamazaki Y., Sugihara T., Goto J-I., Chida K., Fujiwara H., Kaneko K., Fujii S. & Mikoshiba K. (2011) Role of inositol 1, 4, 5-trisphosphate receptors in the postsynaptic expression of guinea pig hippocampal mossy fiber depotentiation. Brain Res. 1387: 19-28.
  33. Goto J, Mikoshiba K. (2011) Inositol 1,4,5-triphosphate receptor-mediated calcium release in purkinje cells: from molecular mechanism to behavior. Cerebellum 10(4): 820-833
  34. Shinohara T, Michikawa T, Enomoto M, Goto J, Iwai M, Matsu-ura T, Yamazaki H, Miyamoto A, Suzuki A, Mikoshiba K.(2011) Mechanistic basis of bell-shaped dependence of inositol 1,4,5-triphosphate receptor gating on cytosolic calcium. Proc Natl Acad Sci USA 108(37): 15486-15491

  35. 【2010】
  36. Jia Y.*, Yamazaki Y.*, Nakauchi S., Ito K-I., & Sumikawa K.(2010) Nicotine facilitates LTP induction in oriens-lacunosum moleculare cells via Ca2+ entry through non-α7 nicotinic acetylcholine receptors. Eur. J. Neurosci. 31: 463-476.
    * These authors contributed equally to this work.
  37. Yamazaki Y., Hozumi Y., Kaneko K., Fujiwara H, Kato H, Fujii S. (2010) Modulation of neuronal activities by interactions between neurons and glial cells. Hirosaki Med. J. 60 (Suppl.): S174-S180.
  38. Fujii S., Yamazaki Y., Kuroda Y. & Mikoshiba K. (2010) Involvement of IP3 receptors in synaptic plasticity induced in hippocampal CA1 neurons by low-frequency stimulation. Neurosci. 168: 346-358.
  39. Yoshioka M., Yamazaki Y., Fujii S., Kaneko K., Kato H. & Mikoshiba K. (2010) Intracellular calcium ion dynamics involved in long-term potentiation in hippocampal CA1 neurons in mice lacking the IP3 type 1 receptor. Neurosci. Res. 67: 149-155.

  40. 【2009】
  41. Jia Y., Yamazaki Y., Nakauchi S. & Sumikawa K. (2009) α2 nicotine receptors function as a molecular switch to continuously excite a subset of interneurons in rat hippocampal circuits. Eur. J. Neurosci. 29: 1588-1603.
  42. Yamazaki Y., Hozumi Y., Kaneko K., Fujii S., Goto K. & Kato H. (2009) Oligodendrocytes: Facilitating axonal conduction by more than myelination. Neuroscientist 16: 11-18.

  43. 【2008】
  44. Tanaka KF., Takebayashi H., Yamazaki Y., Ono K., Naruse M., Iwasato T., Itohara S., Kato H., & Ikenaka K. (2007) The murine model of Alexander disease: analysis of GFAP aggregate formation and its pathological significance. Glia 55: 617‐631.
  45. Fujii S., Yamazaki Y., Sugihara T. & Wakabayashi I (2008) Acute and chronic ethanol exposure differentially affect induction of hippocampal LTP.  Brain Res, 2008; 57: 13-21
  46. Yamazaki Y., Hozumi Y., Kaneko K., Sugihara T.,Fujii S., Goto K. & Kato H. (2008) Modulatory effects of oligodendrocytes on the conduction velocity of action potentials along axons in the alveus of the rat hippocampal CA1 region.  Neuron Glia Biology, 3: 325-334

  47. 【2007】
  48. Nakauchi S., Yamazaki Y., & Sumikawa K. (2007) Chronic nicotine exposure affects the normal operation of hippocampal circuits. NeuroReport 18,87−91.

  49. 【2006】
  50. Yamazaki Y., Jia Y., Rong N. & Sumikawa K. (2006) Nicotine exposure in vivo induces long-lasting enhancement of NMDA receptor-mediated currents in the hippocampus. Eur. J. Neurosci. 23: 1819-1828.
  51. Yamazaki Y., Fujii S., Jia Y. & Sumikawa K. (2006) Nicotine withdrawal suppresses nicotinic modulation of long-term potentiation induction in the hippocampal CA1 region. Eur. J. Neurosci. 24: 2903-2916.
  52. Yamazaki Y., Jia Y., Wong JK. & Sumikawa K. (2006) Chronic nicotine-induced switch in Src-family kinase signaling for long-term potentiation induction in hippocampal CA1 pyramidal cells. Eur. J. Neurosci. 24:3271-3284.

  53. 【2005】
  54. Yamazaki Y., Hozumi Y., Kaneko K., Li J., Fujii S., Miyakawa H, Kudo Y. & Kato H. (2005) Direct evidence for mutual interactions between perineuronal astrocytes and interneurons in the CA1 region of the rat hippocampus. Neuroscience 134: 791-802.
  55. Yamazaki Y., Jia Y., Hamaue N. & Sumikawa K. (2005) Nicotine-induced switch in the nicotinic cholinergic mechanisms of facilitation of long-term potentiation induction. Eur. J. Neurosci. 22: 845-860.
  56. Taufiq AM., Fujii S., Yamazaki Y., Sasaki H., Kaneko K., Li J., Kato H. & Mikoshiba K. (2005) Involvement of IP3 receptors in LTP and LTD induction in guinea pig hippocampal CA1 neurons. Learn. Memory 12: 594-600.

  57. 【2004】
  58. Fujii S., Sasaki H., Mikoshiba K., Kuroda Y., Yamazaki Y., Taufiq AM. & Kato H. (2004) A chemical LTP induced by co-activation of metabotropic and N-methyl-D-aspartate glutamate receptors in hippocampal CA1neurons. Brain Res. 999: 20-28.
  59. Fujii S. (2004) ATP- and adenosine-mediated signaling in the central nervous system:the role of extracellular ATP in hippocampal long-term potentiation. J. Pharmacol. Sci. 94: 103-106.

  60. 【2003】
  61. Yamazaki Y., Kaneko K., Fujii S., Kato H. & Ito K-I. (2003) Long-term potentiation and long-term depression induced by local application of ATP to CA1 hippocampal neurons of the guinea pig. Hippocampus 13: 81-92.
  62. Fujii S., Mikoshiba K., Kuroda Y., Taufiq AM. & Kato H. (2003) Cooperativity between activation of metabotropic glutamate receptors and MDA receptors in the induction of LTP in hippocampal CA1 neurons. Neurosci. Res. 46: 509-521.
  63. Nagase T., Ito K-I., Kato K., Kohda K., Matsumoto M., Hoshino A., Inoue T., Fujii S., Kato H. & Mikoshiba K. (2003) Long-term potentiation aand long-term depression in hippocampal CA1 neurons of mice lacking the IP3 type1 receptor. Neuroscience 117: 821-830.

  64. 【2002】
  65. Fujii S., Kato H. & Kuroda Y. (2002) Effects of temperature on adenosine A1 receptor activation in guinea pig hippocampus in vitro. Pflugers Arch. ? Eur. J. Physiol. 443: 713-719.
  66. Fujii S., Kato H. & Kuroda Y. (2002) Cooperativity between extracellular adenosine 5'-triphosphate and activation of N-methyl-D-aspartate receptors in long-term potentiation induction in hippocampal CA1 neurons. Neuroscience 113: 617-628.
  67. He B., Zhang X., Lian J., Sasaki H., Wu D. & Towle V. L. (2002) Boundary element method-based cortical potential imaging of somatosensory evoked potentials using subjects' magnetic resonance images. Neuroimage 16: 564-576.
  68. Fujii S., Igarashi K., Sasaki H., Furuse H., Ito K-I., Kaneko K., Kato H., Inokuchi J-I., Waki H. & Ando S. (2002) Effects of the mono- and tetrasialogangliosides GM1 and GQ1b on ATP-induced long-term potentitation in hippocampal CA1 neurons. Glycobiology 12: 339-344.
  69. Fujii S., Sasaki H., Ito K-I., Kaneko K. & Kato H. (2002) Temperature dependence of synaptic responses in guinea pig hippocampal CA1 neurons in vitro. Cell. Mol. Neurobiol. 22: 379-391.
  70. Yamazaki Y., Fujii S., Nakamura T., Miyakawa H., Kudo Y., Kato H. & Ito K-I. (2002) Changes in [Ca2+]i during adenosine triphosphate-induced synaptic plasticity in hippocampal CA1 neurons of the guinea pig. Neurosci. Lett. 324: 65-68.
  71. Yamazaki Y., Hamaue N. & Sumikawa K. (2002) Nicotine compensates for the loss of cholinergic function to enhance the induction of long-term potentiation. Brain Res. 946: 148-152.

  72. 【2001】
  73. Fujii S. & Sumikawa K. (2001) Nicotine accelerates reversal of long-term potentiation and enhances long-term depression in the rat hippocampal CA1 region. Brain Res. 894: 340-346.
  74. Fujii S. & Sumikawa K. (2001) Acute and chronic nicotine exposure reverse age-related declines in the induction of long-term potentiation in the rat hippocampus. Brain Res. 894: 347-353.
  75. Itoh S., Ito K-I., Fujii S., Kaneko K., Kato K., Mikoshiba K. & Kato H. (2001) Neuronal plasticity in hippocampal mossy fiber-CA3 synapses of mice lacking the inositol-1,4,5-triphosphate type 1 receptor. Brain Res. 901: 237-246.
  76. Fujii S., Kuroda Y., Li J., Ito K-I., Kaneko K., Sasaki H. & Kato H. (2001) The temperature-dependent modulation of an inhibitory circuit in hippocampal slices as revealed by a population spike recording is mediated by extracellular adenosine. Jpn J. Physiol . 51: 545-554.
  77. Ito K-I. & Hicks T.P. (2001) Effect of the glycine modulatory site of the N-methyl-D-aspartate receptor on synaptic responses in kitten visual cortex. Neurosci. Lett. 303: 95-98.
  78. Ito K-I. & Hicks T.P. (2001) Long-term potentiation of evoked synaptic responses in visual cortical slices from kittens in the critical period. Yamagata Med. J. 19: 85-111.

  79. 【2000】
  80. Fujii S., Kuroda Y., Ito K-I. & Kato H. (2000) LTP induction - a synaptic catch mechanism released by extracellular phosphorylation. Neuroscience 96: 259-266.
  81. Fujii S., Kuroda Y., Ito K-I., Yoshioka M., Kaneko K., Yamazaki Y., Sasaki H. & Kato H. (2000) Endogenous adenosine regulates the effects of low-frequency stimulation on the induction of long-term potentiation in CA1 neurons of guinea pig hippocampal slices. Neurosci. Lett. 279: 121-124.
  82. Fujii S., Kato H., Ito K., Itoh S., Yamazaki Y., Sasaki H. & Kuroda Y. (2000) Effects of adenosine A1 and A2 antagonists on the synaptic and EPSP-spike components of long-term potentiation and depotentiation in the hippocampus. Cell. Mol. Neurobiol. 20: 331-350.
  83. Fujii S., Jia Y., Yang A. & Sumikawa K. (2000) Nicotine reverses GABAergic inhibition of LTP induction in the hippocampal CA1 region. Brain Res. 863: 259-265.
  84. Fujii S., Ji Z. & Sumikawa K. (2000) Inactivation of α7 ACh receptors and activation of non-α7 ACh receptors both contribute to LTP induction in the hippocampal CA1 region. Neurosci. Lett. 286: 134-138.
  85. Fujii S., Matsumoto M., Igarashi K., Kato H. & Mikoshiba K. (2000) Synaptic plasticity in hippocampal CA1 neurons of mice lacking type 1 inositol-1,4,5-trisphosphate receptors. Learn. Memory 7: 312-320.
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発表論文 (和文)
  1. 山崎良彦(2016) オリゴデンドロサイトと神経伝導調節 ―脳白質の機能的可逆性―. 分子精神医学. 2016; 16: 25-31
  2. 藤井聡 (2015) 過重労働と生活習慣病. 成人病と生活習慣病, 2015: 45(5): 596-601
  3. 石川 恵生, 吉田 孝史, 下山 泰明, 藤井 聡, 里見 孝, 濱本 宜興, 飯野 光喜 (2012)歯科技工士の作業管理に関する調査.日本歯科技工学会雑誌 32(2):
  4. 山崎良彦 (2010) 海馬の神経回路におけるニコチンの作用. 日本薬理学雑誌 136:31-35.
  5. 山崎良彦,加藤宏司 (2007) 介在ニューロン付随性グリア細胞による神経活動の修飾.Brain and Nerve 59: 689-695.
  6. 藤井 聡,山崎良彦,佐々木寛,黒田洋一郎 (2007) 記憶・忘却の生理学.Brain Medical 19: 109-119.
  7. 藤井 聡,黒田洋一郎 (2003) 記憶と時間. Brain Med 15:163-172.
  8. 岡崎俊太郎,武田湖太郎,宮崎崇史,安達友希,碓井裕介,松田哲也,佐々木 寛,水野 真,塚田稔,富田 豊 (2002) モルモット聴覚皮質における層構造と周波数選択性、電子情報通信学会技報 NC2001-167: 263-268.
  9. 武田湖太郎,箕輪信太郎,岡崎俊太郎,海老名孝次,松田哲也,高橋 晋,佐々木 寛,水野 真,塚田 稔,富田 豊 (2001) 音刺激によるモルモット聴覚野ニューロンの応答に対する海馬刺激の効果.電子情報通信学会技報 NC2000-176: 153-159.
  10. 藤井 聡 (2000) 海馬におけるシナプス伝達効率の可塑性 −LTP、LTD、depotentiation のメカニズム. Brain Med 12: 7-17.
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著 書 (英文)
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著 書 (和文)
  1. 藤井聡 (2016) 第110回 医師国家試験問題解説書. 東京; 医学評論社
  2. 藤井聡 (2015) 第109回 医師国家試験問題解説書. 東京; 医学評論社
  3. 藤井聡 (2013) CBTこあかり リ・コ 2013 最新問題編 「CBTこあかりリ・コ」編集委員会編, 東京;医学評論社
  4. 藤井聡 (2012) CBTこあかり 1 オリエンテーション 第4版  庄司進一 他編, 東京;医学評論社
  5. 藤井聡 (2012) 国試106 ― 第106回医師国家試験問題解説書 医師国家試験問題解説書編集委員会 編,東京;医学評論社
  6. 藤井聡 (2012) CBTこあかり リ・コ 2012 最新問題編 「CBTこあかりリ・コ」編集委員会編, 東京;医学評論社
  7. 藤井聡 (2011) CBTこあかり リ・コ 2011 オールチェック 「CBTこあかりリ・コ」編集委員会編, 東京;医学評論社
  8. 藤井聡 (2010) CBT こあかり リ・コ 2010 五肢択一形式篇 「CBT こあかりリ・コ」編集委員会編, 東京;医学評論社
  9. 藤井聡 (2010) CBT こあかり リ・コ 2010 連問形式篇 「CBT こあかりリ・コ」編集委員会編, 東京;医学評論社
  10. 藤井聡 (2010) CBT こあかり リ・コ 2010 オールチェック 「CBT こあかりリ・コ」編集委員会編, 東京;医学評論社
  11. 藤井聡 (2009) CBT こあかり リ・コ 2009 五肢択一形式篇 「CBT こあかりリ・コ」編集委員会編,東京,医学評論社
  12. 藤井聡 (2009) CBT こあかり リ・コ 2009 連問形式篇 「CBT こあかりリ・コ」編集委員会編,東京,医学評論社
  13. 藤井聡 (2009) CBT こあかり リ・コ 2009 オールチェック 「CBT こあかりリ・コ」編集委員会編,東京,医学評論社
  14. 藤井聡,山崎良彦 (2008) コアカリ生理学. 医学評論社
  15. 藤井聡 (2008) CBT コアカリ リ・コ 2008 五肢択一形式篇.「CBT こあかり リ・コ」編集委員会編, 医学評論社
  16. 加藤宏司,後藤 薫,藤井 聡,山崎良彦 (2007) 神経科学―脳の探求― Neuroscience: Exploring the Brain, Third edition(監訳)
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その他 (研究報告等)
  1. 藤井 聡,佐々木 寛,須藤俊亮 (2003) 介護作業における業務上腰痛の発生状況と対策に関する研究. 平成14年度産業保健調査研究報告書,労働福祉事業団,pp.1-26.
  2. 佐々木 寛,五十嵐浩太郎,李 建民,金子健也,藤井 聡,伊藤憲一,加藤宏司 (2001) 海馬シナプス可塑性と学習行動の関連を研究するためのマウス学習行動計測システム. 日本学術振興会未来開拓学術研究推進事業研究成果報告書「情報表現の自己組織と学習ニューロチップ」,プロジェクトリーダー 塚田 稔 編, pp.30-34.
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