Major Publications (from 1993 to Present)


 最近の主要な論文 (1993年以降, 2010/09現在)

[太字は教室員, 色字は大学院生学部学生, 2005年までの論文に付したImpact Factor(IF)JCR2009]



Kasahara K, Souri M, Kaneda M, Miki T, Yamamoto N, Ichinose A. Impaired clot retraction in factor XIII A subunit-deficient mice. Blood. 2010;115(6):1277-9. (IF=10.555)


Iwata H, Kitano T, Umetsu K, Yuasa I, Yamazaki K, Kemkes-Matthes B, Ichinose A. Distinct C-terminus of the B subunit of factor XIII in a population-associated major phenotype: the first case of complete allele-specific alternative splicing products in the coagulation and fibrinolytic systems. J Thromb Haemost. 2009;7(7):1084-91. (IF=6.069)


Suzuki T, Ikewaki J, Iwata H, Ohashi Y, Ichinose A. The first two Japanese cases of severe type I congenital plasminogen deficiency with ligneous conjunctivitis: successful treatment with direct thrombin inhibitor and fresh plasma. Am J Hematol. 2009;84(6):363-5. (IF=2.610)


Souri M, Iwata H, Zhang WG, Ichinose A. Unique secretion mode of human protein Z: its Gla domain is responsible for inefficient, vitamin K-dependent and warfarin-sensitive secretion. Blood. 2009;113(16):3857-64. (IF=10.555)


Souri M, Kaetsu H, Ichinose A. Sushi domains in the B subunit of factor XIII responsible for oligomer assembly. Biochemistry. 2008;47(33):8656-64. (IF=3.379)


Palumbo JS, Barney KA, Blevins EA, Shaw MA, Mishra A, Flick MJ, Kombrinck KW, Talmage KE, Souri M, Ichinose A, Degen JL. Factor XIII transglutaminase supports hematogenous tumor cell metastasis through a mechanism dependent on natural killer cell function. J Thromb Haemost. 2008;6(5):812-9. (IF=6.069)


Souri M, Koseki-Kuno S, Takeda N, Yamakawa M, Takeishi Y, Degen JL, Ichinose A. Male-specific cardiac pathologies in mice lacking either the A or B subunit of factor XIII. Thromb Haemost. 2008;99(2):401-8. (IF=4.451)


Souri M, Koseki-Kuno S, Takeda N, Degen JL, Ichinose A. Administration of factor XIII B subunit increased plasma factor XIII A subunit levels in factor XIII B subunit knock-out mice. Int J Hematol. 2008;87(1):60-8. (IF=1.168)


Sugawara H, Iwata H, Souri M, Ichinose A. Regulation of human protein Z gene expression by liver-enriched transcription factor HNF-4alpha and ubiquitous factor Sp1. J Thromb Haemost. 2007;5(11):2250-8. (IF=6.069)


Raut S, Merton RE, Rigsby P, Muszbek L, Seitz R, Ariëns RA, Barrowcliffe TW, Ichinose A; ISTH/SSC Factor XIII Subcommittee and the Factor XIII Standardization Working Party. A collaborative study to establish the 1st International Standard for factor XIII plasma. J Thromb Haemost. 2007;5(9):1923-9. (IF=6.069)


Muszbek L, Ariëns RA, Ichinose A; ISTH SSC SUBCOMMITTEE ON FACTOR XIII. Factor XIII: recommended terms and abbreviations. J Thromb Haemost. 2007;5(1):181-3. (IF=6.069)


Sakuma T, Tanaka M, Inoue J, Mizota A, Souri M, Ichinose A. Use of autologous plasmin during vitrectomy for diabetic maculopathy. Eur J Ophthalmol. 2006;16(1):138-40. (IF=0.887)


Sakuma T, Tanaka M, Inoue M, Mizota A, Souri M, Ichinose A. Efficacy of autologous plasmin for idiopathic macular hole surgery. Eur J Ophthalmol. 2005;15(6):787-94. (IF=0.887)


Iwata H, Souri M, Kemkes-Matthes B, Ichinose A. An additional Glu30Lys substitution in the Gla domain of the protein Z gene is not a common polymorphism but a rare mutation, which would cause its deficiency. J Thromb Haemost. 2005;3(10):2360-1. (IF=6.069)


(Review) Ichinose A, Asahina T, Kobayashi T. Congenital blood coagulation factor XIII deficiency and perinatal management. Curr Drug Targets. 2005;6(5):541-9. (IF=3.932)


(Review) Ichinose A. Extracellular transglutaminase: factor XIII. Prog Exp Tumor Res. 2005;38:192-208. (IF=0.423)


Kemkes-Matthes B, Matthes KJ, Souri M, Koseki-Kuno S, Ichinose A. R255h amino acid substitution of protein Z identified in patients with factor V Leiden mutation. Br J Haematol. 2005;128(2):248-52. (IF=4.597)


Souri M, Koseki-Kuno S, Iwata H, Kemkes-Matthes B, Ichinose A. A naturally occurring E30Q mutation in the Gla domain of protein Z causes its impaired secretion and subsequent deficiency. Blood. 2005;105(8):3149-54. (IF=10.555)


Sakuma T, Tanaka M, Souri M, Ichinose A. [Preparation of high-purity and safe autologous plasmin and its clinical application]. Nippon Ganka Gakkai Zasshi. 2003;107(11):709-18. Japanese. [佐久間俊郎,田中 稔,惣宇利正善一瀬白帝:酵素を用いた硝子体手術に用いる自己血由来プラスミンの作製法の改良とその臨床応用.日本眼科学会雑誌 2003; 107(11): 709-18.]


Koseki-Kuno S, Yamakawa M, Dickneite G, Ichinose A. Factor XIII A subunit-deficient mice developed severe uterine bleeding events and subsequent spontaneous miscarriages. Blood. 2003;102(13):4410-2.


Okumura T, Yamada T, Park SC, Ichinose A. No Val34Leu polymorphism of the gene for factor XIIIA subunit was detected by ARMS-RACE method in three Asian populations. J Thromb Haemost. 2003;1(8):1856-7.


(Review) Bergamini CM, Eckert RL, Ichinose A, Muszbek L, Squerzanti M. Cellular differentiation and death in a renaissance castle. Cell Death Differ. 2003;10(2):262-5.


(Review) Ichinose A: Factor XIII: state of the art. Minerva Biotech., 2002; 14: 121-8.


(Review) Ichinose A: Protein Z. Wiley Encyclopedia of Molecular Medicine, 2002; pp.2654-6.


Souri M, Ichinose A. Impaired protein folding, dimer formation, and heterotetramer assembly cause intra- and extracellular instability of a Y283C mutant of the A subunit for coagulation factor XIII. Biochemistry. 2001;40(45):13413-20.


(Review) Ichinose A. Physiopathology and regulation of factor XIII. Thromb Haemost. 2001;86(1):57-65.


Souri M, Yee VC, Kasai K, Kaneshiro T, Narasaki K, Castaman G, Ichinose A. Novel Y283C mutation of the A subunit for coagulation factor XIII: molecular modelling predicts its impaired protein folding and dimer formation. Br J Haematol. 2001;113(3):652-4.


Koseki S, Souri M, Koga S, Yamakawa M, Shichishima T, Maruyama Y, Yanai F, Ichinose A. Truncated mutant B subunit for factor XIII causes its deficiency due to impaired intracellular transportation. Blood. 2001;97(9):2667-72.


(Books) Chung DC, Pratt KP, Ichinose A: Disorders of Fibrinogen and Factor XIII. Metabolic and Molecular Bases of Inherited Disease, 8th Edition, McGraw-Hill Book Company, N.Y., 2001, pp.4345-66.


(Review) Ichinose A, Souri M, Izumi T, Takahashi N. Molecular and genetic mechanisms of factor XIII A subunit deficiency. Semin Thromb Hemost. 2000;26(1):5-10.


(Review) Ichinose A: Hyper-Lipoprotein(a)-emia, Atherosclerosis, and Thrombosis. Acta. Gerontologica., 1999; 44(1/2); 29-36.


Ooe A, Kida M, Yamazaki T, Park SC, Hamaguchi H, Girolami A, Ichinose A. Common mutation of plasminogen detected in three Asian populations by an amplification refractory mutation system and rapid automated capillary electrophoresis. Thromb Haemost. 1999;82(4):1342-6.


Tateno T, Ichinose A. Expression of plasminogen-related gene B varies among normal tissues and increases in cancer tissues. FEBS Lett. 1999;445(1):31-5.


Kida M, Souri M, Yamamoto M, Saito H, Ichinose A. Transcriptional regulation of cell type-specific expression of the TATA-less A subunit gene for human coagulation factor XIII. J Biol Chem. 1999;274(10):6138-47.


Murata M, Saito T, Takahashi S, Ichinose A. Plasma lipoprotein(a) levels are high in patients with central retinal artery occlusion. Thromb Res. 1998;91(4):169-75.


(Review) Ichinose A, Suzuki K, Takabatake N, Saito T. Multi-modal expression of apolipoprotein (a) gene in vivo. J Atheroscler Thromb. 1998;4(3):107-11.


Takabatake N, Souri M, Ichinose A. Multiple novel transcripts for apolipoprotein(a)-related gene II generated by alternative splicing in tissue- and cell type-specific manners. J Biochem. 1998;124(3):540-6.


Souri M, Izumi T, Higashi Y, Girolami A, Ichinose A. A founder effect is proposed for factor XIII B subunit deficiency caused by the insertion of triplet AAC in exon III encoding the second Sushi domain. Thromb Haemost. 1998;80(2):211-3.


(Review) Ichinose A, Suzuki K, Saito T. Apolipoprotein(a) and thrombosis: molecular and genetic bases of hyper-lipoprotein(a)-emia. Semin Thromb Hemost. 1998;24(3):237-43.


Fujimaki K, Yamazaki T, Taniwaki M, Ichinose A. The gene for human protein Z is localized to chromosome 13 at band q34 and is coded by eight regular exons and one alternative exon. Biochemistry. 1998;37(19):6838-46.


Ichinose A, Tsukamoto H, Izumi T, Yamazaki T, Togashi M, Takamatsu J, Saito H, Umeyama H. Arg260-Cys mutation in severe factor XIII deficiency: conformational change of the A subunit is predicted by molecular modelling and mechanics. Br J Haematol. 1998;101(2):264-72.


Takahashi N, Tsukamoto H, Umeyama H, Castaman G, Rodeghiero F, Ichinose A. Molecular mechanisms of type II factor XIII deficiency: novel Gly562-Arg mutation and C-terminal truncation of the A subunit cause factor XIII deficiency as characterized in a mammalian expression system. Blood. 1998;91(8):2830-8.


Izumi T, Nagaoka U, Saito T, Takamatsu J, Saito H, Ichinose A. Novel deletion and insertion mutations cause splicing defects, leading to severe reduction in mRNA levels of the A subunit in severe factor XIII deficiency. Thromb Haemost. 1998;79(3):479-85.


Yamada T, Yoshiyama Y, Kawaguchi N, Ichinose A, Iwaki T, Hirose S, Jefferies WA. Possible roles of transglutaminases in Alzheimer's disease. Dement Geriatr Cogn Disord. 1998;9(2):103-10.


Kida M, H-Kawabata M, Yamazaki T, Ichinose A. Presence of two plasminogen alleles in normal populations. Thromb Haemost. 1998 Jan;79(1):150-4.


Murata M, Ooe A, Izumi T, Nakagawa M, Takahashi S, Ishikawa M, Mori K, Ichinose A. Ala601-Thr type dysplasminogenaemia genetically diagnosed in patients with retinochoroidal vascular disorders. Br J Haematol. 1997;99(2):301-3.


Saito T, Ookubo R, Kuriyama M, Sano R, Ichinose A. Lipoprotein(a) concentration and molecular weight of apolipoprotein(a) in patients with cerebrovascular disease and diabetes mellitus. Thromb Res. 1997;87(6):527-38.


Suzuki K, Kuriyama M, Saito T, Ichinose A. Plasma lipoprotein(a) levels and expression of the apolipoprotein(a) gene are dependent on the nucleotide polymorphisms in its 5'-flanking region. J Clin Invest. 1997;99(6):1361-6.


Kida M, Wakabayashi S, Ichinose A. Characterization of the 5'-flanking regions of plasminogen-related genes A and B. FEBS Lett. 1997;404(1):95-9.


Kida M, Wakabayashi S, Ichinose A. Expression and induction by IL-6 of the normal and variant genes for human plasminogen. Biochem Biophys Res Commun. 1997;230(1):129-32.


Tsutsumi S, Saito T, Sakata T, Miyata T, Ichinose A. Genetic diagnosis of dysplasminogenemia: detection of an Ala601-Thr mutation in 118 out of 125 families and identification of a new Asp676-Asn mutation. Thromb Haemost. 1996;76(2):135-8.


Kaetsu H, Hashiguchi T, Foster D, Ichinose A. Expression and release of the a and b subunits for human coagulation factor XIII in baby hamster kidney (BHK) cells. J Biochem. 1996;119(5):961-9.


Izumi T, Hashiguchi T, Castaman G, Tosetto A, Rodeghiero F, Girolami A,Ichinose A. Type I factor XIII deficiency is caused by a genetic defect of its b subunit: insertion of triplet AAC in exon III leads to premature termination in the second Sushi domain. Blood. 1996;87(7):2769-74.


Takei H, Araki A, Watanabe H, Ichinose A, Sendo F. Rapid killing of human neutrophils by the potent activator phorbol 12-myristate 13-acetate (PMA) accompanied by changes different from typical apoptosis or necrosis. J Leukoc Biol. 1996;59(2):229-40.


(Review) Ichinose A, Izumi T, Hashiguchi T. The normal and abnormal genes of the a and b subunits in coagulation factor XIII. Semin Thromb Hemost. 1996;22(5):385-91.


Ichinose A, Kuriyama M. Detection of polymorphisms in the 5'-flanking region of the gene for apolipoprotein(a). Biochem Biophys Res Commun. 1995;209(1):372-8.


Ichinose A. Characterization of the apolipoprotein(a) gene. Biochem Biophys Res Commun. 1995;209(1):365-71.


Hashiguchi T, Ichinose A. Molecular and cellular basis of deficiency of the b subunit for factor XIII secondary to a Cys430-Phe mutation in the seventh Sushi domain. J Clin Invest. 1995;95(3):1002-8.


Hashiguchi T, Saito M, Morishita E, Matsuda T, Ichinose A. Two genetic defects in a patient with complete deficiency of the b-subunit for coagulation factor XIII. Blood. 1993;82(1):145-50.