Department of Molecular Patho-Biochemistry and Patho-Biology of Hematology and Circulation
Cloners and Clotters
Professor: Akitada Ichinose, M.D. & Ph. Ds. (in Science and in Medicine)
Lecturer: Masayoshi Souri, Ph. D. (in Medicine) & B.S.
Instructor: Hiroki Iwata, B.S.
Secretory: Yuriko Domon-Shibue
The Department of Molecular Pathological Biochemistry of Yamagata University was established in 1987 in the School of Medicine by the effort of its Dean Shozo Tsuboi, former President of the University. The first chairman was Prof. Tadashi Yoshida (former Asst. Prof. of Biochemistry I). Dr. Michihiko Sato was appointed to Asst. Prof. of the department in 1988 and moved to the Center for Education and Research Aids in 1992. Since Prof. Yoshida returned to the Department of Biochemistry I in 1991, Prof. Akitada Ichinose, from the University of Washington, Seattle, was invited to assume the chairmanship in 1992. Dr. Teruto Hashiguchi served as an instructor from 1992 through 1994, Drs. Tomonori Izumi and Tetsuo Saito from 1994 through 1996, and Dr. Tomio Yamazaki from 1996 through 1998. The current instructors, Drs. Masayoshi Souri and Shiori Koseki joined in 1997 and 1999, respectively. Dr. Souri has been promoted to a lecturer in 2000. In April 1995, Prof. Ichinose published the first textbook for Molecular Patho-Biochemistry and Patho-Biology, and revised it in September 1998. The department's first graduate student completed his dissertation in March of 1995 (paper 5 by S. T. as listed below), three in March of 1996 (paper 8 by K. S., paper 14 by N. T., and paper 16 by K. F.), and three in March of 1997 (paper 19 by N. T., paper 22 by M. K., and paper 23 by T. T.). Currently, two graduate students are studying the molecular biology of blood coagulation, fibrinolysis and atherosclerosis, among other topics.
In order to introduce undergraduate students to the basic concepts of molecular disease, formal lecture courses (48 hours in 2006) cover the following topics: 1) general aspects of cellular and molecular biology & biochemistry; 2) techniques in molecular biology and genetics; 3) genetic diagnosis and treatment; 4) molecular mechanisms of cancer including leukemia, thrombosis and bleeding disorders, neurological diseases and myopathies, atherosclerosis and hyperlipidemia, metabolic diseases, etc. In a literature review course, students select recent original articles for intensive analysis before leading class discussion on the topics. They also take a lab course of 50 hours (in 2006) in which five separate experiments are performed.
Some students can also select the advenced course of the molecular-biochemistry, in which the most essential technology of molecular-biology are indrodenced in (20hrs) details as well as in concret terms.
For graduate students, special lectures are given two or three times per week by the faculty and invited lecturers (1st & 2nd year). These students also attend one Journal Club per week, in Molecular Hematology or general Molecular Medicine. Students are also introduced to a variety of basic laboratory techniques in molecular biology, including preparations of DNA, PCR, restriction digestion, subcloning, and nucleotide sequencing, computer-assisted analysis, etc., in a beginning lab course (typically in 1st year). After completion of the primary practice, each graduate student starts to work on an individual research project toward the Ph.D. thesis (typically from 2nd year). Students present their research progress every other week at a departmental research conference. At the end of the 4th year, they must submit a paper and defend their doctoral dissertation.
Main Topics of Research
Our major research efforts have been focused on the molecular and cellular bases of bleeding tendencies, thrombotic disorders, and atherosclerosis in which 1) Coagulation Factor XIII, 2) <Apo-Plg.gif>Plasminogen, 3) Apolipoprotein(a), 4) Protein Z, etc. are involved.
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