Yuji Takeda, Ph.D.
Department of Immunology, Yamagata University, Faculty of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan
TEL +81-23-628-5265 FAX +81-23-628-5267


1.       Takeda, Y., T. Shimomura, H. Asao, I. Wakabayashi. 2017. Relationship between Immunological Abnormalities in Rat Models of Diabetes Mellitus and the Amplification Circuits for Diabetes. Journal of Diabetes Research, vol. 2017, Article ID 4275851, 9 pages, 2017. doi:10.1155/2017/4275851.

2.       Takeda, Y., M. Marumo, H. Nara, Z. G. Feng, H. Asao, and I. Wakabayashi. 2016. Selective induction of anti-inflammatory monocyte-platelet aggregates in a model of pulsatile blood flow at low shear rates. Platelets 27:583-592.

3.       Takeda, Y., T. Kato, H. Ito, Y. Kurota, A. Yamagishi, T. Sakurai, A. Araki, H. Nara, N. Tsuchiya, and H. Asao. 2016. The pattern of GPI-80 expression is a useful marker for unusual myeloid maturation in peripheral blood. Clin Exp Immunol 186:373-386.

4.      Tachibana, H., R. Sho, Y. Takeda, X. Zhang, Y. Yoshida, H. Narimatsu, K. Otani, S. Ishikawa, A. Fukao, H. Asao, and M. Iino. 2016. Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target. PLoS One 11:e0159693.

5.       Akhter, N., Y. Takeda, H. Nara, A. Araki, N. Ishii, N. Asao, and H. Asao. 2016. Apurinic/apyrimidinic endonuclease 1/redox factor-1 (Ape1/Ref-1) modulates antigen presenting cell-mediated T helper cell type 1 responses. J Biol Chem.

6.       Takeda, Y., T. Shimomura, and I. Wakabayashi. 2014. Immunological disorders of diabetes mellitus in experimental rat models. Nihon Eiseigaku Zasshi 69:166-176.

7.       Takeda, Y., H. Nara, A. Araki, and H. Asao. 2014. Human peripheral neutrophils express functional IL-21 receptors. Inflammation 37:1521-1532.     

8.       Wakabayashi, I., and Y. Takeda. 2013. Inhibitory effects of resveratrol on MCP-1, IL-6, and IL-8 production in human coronary artery smooth muscle cells. Naunyn Schmiedebergs Arch Pharmacol 386:835-839.                          

9.       Takeda, Y., K. Kaneda, F. Jimma, N. Shiobara, A. R. Saniabadi, and I. Wakabayashi. 2013. Suppression of Th1 cytokine production by a peptide derived from C4b. Inflamm Res 62:951-959.                                        

10.     Nara, H., M. Rahman, A. Araki, L. Jin, Y. Takeda, and H. Asao. 2013. IL-21 isoform is a membrane-bound ligand and activates directly interacted cells. Cytokine 61:656-663.                                              

11.      Hidaka, M., I. Wakabayashi, Y. Takeda, and K. Fukuzawa. 2013. Vitamin D3 derivatives increase soluble CD14 release through ERK1/2 activation and decrease IL-8 production in intestinal epithelial cells. Eur J Pharmacol 721:305-312.                                                                  

12.     Araki, A., H. Nara, M. Rahman, T. Onoda, J. Li, F. M. Juliana, L. Jin, K. Murata, Y. Takeda, and H. Asao. 2013. Role of interleukin-21 isoform in dextran sulfate sodium (DSS)-induced colitis. Cytokine 62:262-271.                     

13.     Takeda, Y., and I. Wakabayashi. 2012. Alteration in lymphocyte population and humoral immune response in type 2 diabetic Goto-Kakizaki rats. Life Sci 90:545-552.                                                         

14.     Takeda, Y., K. Kaneda, F. Jimma, N. Shiobara, M. Hidaka, A. R. Saniabadi, and I. Wakabayashi. 2012. Inhibition of CXCL10 release by monomeric C3bi and C4b. Clin Exp Immunol 167:149-157.                             

15.     Marumo, M., T. Nakano, Y. Takeda, K. Goto, and I. Wakabayashi. 2012. Inhibition of thrombin-induced Ca(2)(+) influx in platelets by R59949, an inhibitor of diacylglycerol kinase. J Pharm Pharmacol 64:855-861.   

16.     Takeda, Y., M. Marumo, and I. Wakabayashi. 2011. Attenuated phagocytic activity of monocytes in type 2 diabetic Goto-Kakizaki rats. Immunobiology 216:1094-1102.                                                                     

17.     Hanai, H., Y. Takeda, M. Eberhardson, R. Gruber, A. R. Saniabadi, O. Winqvist, and R. Lofberg. 2011. The mode of actions of the Adacolumn therapeutic leucocytapheresis in patients with inflammatory bowel disease: a concise review. Clin Exp Immunol 163:50-58.

18.     Takeda, Y., M. Ohba, M. Ueno, A. R. Saniabadi, and I. Wakabayashi. 2010. Cellulose acetate beads activate the complement system but inactivate the anaphylatoxins generated. Artif Organs 34:1144-1149.             

19.     Nishise, S., Y. Takeda, S. Fujishima, T. Orii, T. Sato, Y. Sasaki, Y. Nishise, H. Takeda, and S. Kawata. 2010. Release of interleukin-1 receptor antagonist by combining a leukocyte adsorption carrier with ulinastatin. Ther Apher Dial 14:386-391.

20.     Jimma, F., Y. Takeda, K. Kaneda, and I. Wakabayashi. 2010. Induction of Foxp3 expression in T cells by cellulose acetate beads in vitro. J Clin Apher 25:216-222.

21.     Nishise, S., Y. Takeda, Y. Nishise, S. Fujishima, T. Orii, S. Otake, T. Sato, Y. Sasaki, H. Takeda, and S. Kawata. 2009. Biological effect of anaphylatoxin C5a on the generation of anti-inflammatory substances in leukocyte adsorption. Ther Apher Dial 13:509-514.

22.     Takeda, H., Y. Suzuki, Y. Takeda, S. Nishise, T. Fukui, S. Fujishima, T. Orii, S. Otake, T. Sato, K. Suzuki, Y. Nakamuara, and S. Kawata. 2008. A multi center study of granulocyte and monocyte adsorption apheresis therapy for ulcerative colitis-Clinical efficacy and production of interleukin-1 receptor antagonist. J Clin Apher 23:105-110.

23.     Takeda, Y., H. Asaoka, M. Ueno, F. Jimma, M. Hidaka, H. Shibusawa, K. Kaneda, A. R. Saniabadi, K. Hiraishi, and N. Kashiwagi. 2007. Assessment of rabbit spleen size using ultrasonography. J Vet Med Sci 69:841-842.

24.     Nitto, T., Y. Takeda, H. Yoshitake, F. Sendo, and Y. Araki. 2007. Structural divergence of GPI-80 in activated human neutrophils. Biochem Biophys Res Commun 359:227-233.                                                    

25.     Sakimura, K., T. Omori, E. Iwashita, T. Yoshida, Y. Tsuzuki, K. Fujimori, F. Konishi, Y. Yoshida, H. Anzai, H. Suzuki, S. Sugawara, Y. Takeda, K. Hiraishi, A. R. Saniabadi, T. Ide, S. Miura, and S. Ota. 2006. Clinical response is associated with elevated plasma interleukin-1 receptor antagonist during selective granulocyte and monocyte apheresis in patients with ulcerative colitis. Dig Dis Sci 51:1525-1531.

26.     Nishise, S., Y. Takeda, H. Takeda, K. Ishihama, T. Fukui, and S. Kawata. 2006. Complement activation is involved in biological responses to leukocyte adsorptive apheresis. Dig Dis Sci 51:934-941.

27.     Inoue, T., T. Kato, Y. Hikichi, S. Hashimoto, T. Hirase, T. Morooka, Y. Imoto, Y. Takeda, F. Sendo, and K. Node. 2006. Stent-induced neutrophil activation is associated with an oxidative burst in the inflammatory process, leading to neointimal thickening. Thromb Haemost 95:43-48.                              

28.     Saniabadi, A. R., H. Hanai, Y. Suzuki, T. Ohmori, K. Sawada, N. Yoshimura, Y. Saito, Y. Takeda, K. Umemura, K. Kondo, Y. Ikeda, K. Fukunaga, M. Nakashima, A. Beretta, I. Bjarnason, and R. Lofberg. 2005. Adacolumn for selective leukocytapheresis as a non-pharmacological treatment for patients with disorders of the immune system: an adjunct or an alternative to drug therapy? J Clin Apher 20:171-184.

29.     Fu, J. F., Y. Takeda, F. Sendo, and Y. Araki. 2005. [Different impacts of DMSO and RA on GPI-80 expression]. Shi Yan Sheng Wu Xue Bao 38:37-44.

30.     Anzai-Takeda, Y., Y. Takeda, F. Sendo, and Y. Araki. 2005. Inhibition of cell spreading in CHO cells transfected with cDNA of a glycosylphosphatidyl inositol-anchored protein, GPI-80. Immunobiology 210:1-10.                     

31.     Takeda, Y., N. Shiobara, A. R. Saniabadi, M. Adachi, and K. Hiraishi. 2004. Adhesion dependent release of hepatocyte growth factor and interleukin-1 receptor antagonist from human blood granulocytes and monocytes: evidence for the involvement of plasma IgG, complement C3 and beta2 integrin. Inflamm Res 53:277-283.

32.     Huang, J. B., Y. Takeda, Y. Araki, F. Sendo, and H. R. Petty. 2004. Molecular proximity of complement receptor type 3 (CR3) and the glycosylphosphatidylinositol-linked protein GPI-80 on neutrophils: effects of cell adherence, exogenous saccharides, and lipid raft disrupting agents. Mol Immunol 40:1249-1256.                                                     

33.     Yoshitake, H., Y. Takeda, T. Nitto, F. Sendo, and Y. Araki. 2003. GPI-80, a beta2 integrin associated glycosylphosphatidylinositol-anchored protein, concentrates on pseudopodia without association with beta2 integrin during neutrophil migration. Immunobiology 208:391-399.                                   

34.     Takeda, Y., K. Hiraishi, H. Takeda, N. Shiobara, H. Shibusawa, A. R. Saniabadi, M. Adachi, and S. Kawata. 2003. Cellulose acetate beads induce release of interleukin-1 receptor antagonist, but not tumour necrosis factor-alpha or interleukin-1beta in human peripheral blood. Inflamm Res 52:287-290.

35.     Takeda, Y., J. Fu, K. Suzuki, D. Sendo, T. Nitto, F. Sendo, and Y. Araki. 2003. Expression of GPI-80, a beta2-integrin-associated glycosylphosphatidylinositol-anchored protein, requires neutrophil differentiation with dimethyl sulfoxide in HL-60 cells. Exp Cell Res 286:199-208.                                                                                    

36.     Sendo, D., Y. Takeda, H. Ishikawa, F. Sendo, and Y. Araki. 2003. Localization of GPI-80, a beta2-integrin-associated glycosylphosphatidyl-inositol anchored protein, on strongly CD14-positive human monocytes. Immunobiology 207:217-221.                                                                         

37.     Sasaki, H., N. Ide, F. Sendo, Y. Takeda, M. Adachi, I. Fukai, and Y. Fujii. 2003. Glycosylphosphatidyl inositol-anchored protein (GPI-80) gene expression is correlated with human thymoma stage. Cancer Sci 94:809-813.       

38.     Hiraishi, K., Y. Takeda, N. Shiobara, H. Shibusawa, F. Jimma, N. Kashiwagi, A. R. Saniabadi, and M. Adachi. 2003. Studies on the mechanisms of leukocyte adhesion to cellulose acetate beads: an in vitro model to assess the efficacy of cellulose acetate carrier-based granulocyte and monocyte adsorptive apheresis. Ther Apher Dial 7:334-340.

39.     Yoshitake, H., Y. Takeda, T. Nitto, and F. Sendo. 2002. Cross-linking of GPI-80, a possible regulatory molecule of cell adhesion, induces up-regulation of CD11b/CD18 expression on neutrophil surfaces and shedding of L-selectin. J Leukoc Biol 71:205-211.                                                         

40.     Nitto, T., Y. Araki, Y. Takeda, and F. Sendo. 2002. Pharmacological analysis for mechanisms of GPI-80 release from tumour necrosis factor-alpha-stimulated human neutrophils. Br J Pharmacol 137:353-360.                         

41.     Koike, S., Y. Takeda, Y. Hozumi, S. Okazaki, M. Aoyagi, and F. Sendo. 2002. Immunohistochemical localization in human tissues of GPI-80, a novel glycosylphosphatidyl inositol-anchored protein that may regulate neutrophil extravasation. Cell Tissue Res 307:91-99.                                           

42.    Huang, J., Y. Takeda, T. Watanabe, and F. Sendo. 2001. A sandwich ELISA for detection of soluble GPI-80, a glycosylphosphatidyl-inositol (GPI)-anchored protein on human leukocytes involved in regulation of neutrophil adherence and migration--its release from activated neutrophils and presence in synovial fluid of rheumatoid arthritis patients. Microbiol Immunol 45:467-471.     

43.     Suzuki, K., T. Watanabe, S. Sakurai, K. Ohtake, T. Kinoshita, A. Araki, T. Fujita, H. Takei, Y. Takeda, Y. Sato, T. Yamashita, Y. Araki, and F. Sendo. 1999. A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: a possible role for regulation of neutrophil adherence and migration. J Immunol 162:4277-4284.                                                                      

44.     Sendo, F., K. Suzuki, T. Watanabe, Y. Takeda, and Y. Araki. 1998. Modulation of leukocyte transendothelial migration by integrin-associated glycosyl phosphatidyl inositol (GPI)-anchored proteins. Inflamm Res 47 Suppl 3:S133-136.

45.     Gon, S., S. Saito, Y. Takeda, H. Miyata, K. Takatsu, and F. Sendo. 1997. Apoptosis and in vivo distribution and clearance of eosinophils in normal and Trichinella spiralis-infected rats. J Leukoc Biol 62:309-317.                  

46.     Takeda, Y., S. Gon, H. Takei, and F. Sendo. 1996. [TNF/TNFR gene and apoptosis]. Nippon Rinsho 54:1888-1894.

47.     Sendo, F., H. Tsuchida, Y. Takeda, S. Gon, H. Takei, T. Kato, O. Hachiya, and H. Watanabe. 1996. Regulation of neutrophil apoptosis--its biological significance in inflammation and the immune response. Hum Cell 9:215-222.

48.     Tsuchida, H., Y. Takeda, H. Takei, H. Shinzawa, T. Takahashi, and F. Sendo. 1995. In vivo regulation of rat neutrophil apoptosis occurring spontaneously or induced with TNF-alpha or cycloheximide. J Immunol 154:2403-2412.

49.     Kato, T., Y. Takeda, T. Nakada, and F. Sendo. 1995. Inhibition by dexamethasone of human neutrophil apoptosis in vitro. Nat Immun 14:198-208.

50.     Hachiya, O., Y. Takeda, H. Miyata, H. Watanabe, T. Yamashita, and F. Sendo. 1995. Inhibition by bacterial lipopolysaccharide of spontaneous and TNF-alpha-induced human neutrophil apoptosis in vitro. Microbiol Immunol 39:715-723.                                                                          

51.     Takeda, Y., H. Watanabe, S. Yonehara, T. Yamashita, S. Saito, and F. Sendo. 1993. Rapid acceleration of neutrophil apoptosis by tumor necrosis factor-alpha. Int Immunol 5:691-694.