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Toshihiro KURAHASHI

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Original Papers

  1. Shinji Hamashima, Takujiro Homma, Sho Kobayashi, Naoki Ishii, Toshihiro Kurahashi, Ren Watanabe, Naoko Kimura, Hideyo Sato, Junichi Fujii.
    Decreased reproductive performance in xCT-knockout male mice.
    Free Radic Res, 51:851-860 (2017)
  2. Eun Sil Kang, Jaeyong Lee, Takujiro Homma, Toshihiro Kurahashi, Sho Kobayashi, Atsunori Nabeshima, Sohsuke Yamada, Han Geuk Seo, Satoshi Miyata, Hideyo Sato, Junichi Fujii
    xCT deficiency aggravates acetaminophen-induced hepatotoxicity under inhibition of the transsulfuration pathway

    Free Radic Res, 51, 80-90 (2017)  DOI: 10.1080/10715762.2017.1282157 ) 
  3. Eisuke Tasaka, Shotaro Matsumoto, Hisashi Tada, Toshihiro Kurahashi, Xuhong Zhang, Junichi Fujii, Toshihiko Utsumi, Yoshihito Iuchi.
    Protective role of testis-specific peroxiredoxin 4 against cellular oxidative stress. 
    J Clin Biochem Nutr, 60:156-161 (2017)
  4. Takaya Shirato, Takujiro Homma, Jaeyong Lee, Toshihiro Kurahashi, Junichi Fujii.
    Oxidative stress caused by a SOD1 deficiency ameliorates thioacetamide-triggered cell death via CYP2E1 inhibition but stimulates liver steatosis.
    Arch Toxicol, 91:1319-1333 (2017) 
  5. Junitsu  Ito, Naoki  Ishii, Ryusuke  Akihara, Jaeyong  Lee, Toshihiro  Kurahashi, Takujiro  Homma, Ryo  Kawasaki, Junichi Fujii.
    A high fat diet temporarily renders Sod1-deficient mice resistant to an oxidative insult.
    J Nutr Biochem, 40:44-52 (2017)
  6. Toshihiro Kurahashi, Jaeyong Lee, Atsunori Nabeshima, Takujiro Homma, Eun Sil Kang, Yuka Saito, Sohsuke Yamada, Toshiyuki Nakayama, Ken-ichi Yamada, Satoshi Miyata, Junichi Fujii.
    Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy.
    Arch Biochem Biophys, 604:36-46 (2016)
  7. Noriyuki Otsuki, Takujiro Homma, Hiroki Fujiwara, Kenya Kaneko, Yasukazu Hozumi, Mototada Shichiri, Mizuki Takashima, Junitsu Ito, Tasuku Konno, Toshihiro Kurahashi, Yasukazu Yoshida, Kaoru Goto, Satoshi Fujii,Junichi Fujii.
    Trichloroethylene exposure aggravates behavioral abnormalities in mice that are deficient in superoxide dismutase.
    Regul Toxicol Pharmacol. 79:83-90 (2016) doi: 10.1016/j.yrtph.2016.05.007.
  8. Noriyuki Otsuki, Tasuku Konno, Toshihiro Kurahashi, Saori Suzuki, Jaeyong Lee,Futoshi Okada, Yoshihito Iuchi, Takujiro Homma, Junichi Fujii,
    The SOD1 transgene expressed in erythroid cells alleviates fatal phenotype in congenic NZB/NZW-F1 mice.
    Free Radic Res, 50(7):793-800 (2016) doi: 10.1080/10715762.2016.1178388.
  9. Aya Nawata, Hirotsugu Noguchi, Yuichi Mazaki, Toshihiro Kurahashi, Atsunori Nabeshima, Ke-Yong Wang, Satoshi Kimura, Hidetaka Uramoto, Kimitoshi Kohno, Hatsumi Taniguchi, Yoshiya Tanaka, Junichi Fujii, Yasuyuki Sasaguri Toshiyuki Nakayama, and Sohsuke Yamada.
    Overexpression of Peroxiredoxin 4 Induces Adaptive Intestinal Lipid Metabolism Associated with Suppressive Nonalcoholic Steatohepatitis in a Dietary Mouse Model.
    PLoS One, 11: e015254, (2016)
  10. Toshihiro Kurahashi, Shinji Hamashima, Takaya Shirato, Jaeyong Lee, Takujiro Homma, Eun Sil Kang, Junichi Fujii.
    An SOD1 deficiency enhances lipid droplet accumulation in the fasted mouse liver by aborting lipophagy

    Biochem Biophys Res Commun, ,467:866-871 (2015)
  11. Takujiro Homma, Toshihiro Kurahashi, Jaeyong Lee, Eun Sil Kang, and Junichi Fujii
    SOD1 deficiency decreases proteasomal function, leading to the accumulation of ubiquitinated proteins in erythrocytes.
    Arch Biochem Biophys, 583:65-72 (2015)  
  12. Jaeyong Lee, Takujiro Homma, Toshihiro Kurahashi, Eun Sil Kang, andJunichi Fujii.
    Oxidative stress triggers lipid droplet accumulation in primary cultured hepatocytes by activating fatty acid synthesis.

    Biochem Biophys Res Commun
    , 464:229-235 (2015)
  13. Takujiro Homma, Satoshi Okano, Jaeyong Lee, Junitsu Ito, Noriyuki Otsuki, Toshihiro Kurahashi, Eun Sil Kang, Osamu Nakajima, and Junichi Fujii.
    SOD1 deficiency induces the systemic hyperoxidation of peroxiredoxin in the mouse.
    Biochem Biophys Res Commun
    ,463:1040-1046 (2015) 
  14. Toshihiro Kurahashi, Myoungsu Kwon, Takujiro Homma, Yuka Saito, Jaeyong Lee, Motoko Takahashi, Ken-ichi Yamada, Satoshi Miyata, and Junichi Fujii.
    Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals.  
    Biochem Biophys Res Commun, 452:136-141 (2014) 
  15. Hayato Nishida, Toshihiro Kurahashi, Yuka Saito, Noriyuki Otsuki, Myoungsu Kwon, Hiroya Ohtake, Mitsunori Yamakawa, Ken-ichi Yamada, Satoshi Miyata, Yoshihiko Tomita, and Junichi Fujii.
    Kidney fibrosis is independent of the amount of ascorbic acid in mice with unilateral ureteral obstruction.
    Free Radic Res, 48(9):1115-1124 (2014) 
  16. Junitsu Ito, Noriyuki Otsuki, Xuhong Zhang, Tasuku Konno, Toshihiro Kurahashi, Motoko Takahashi, Mayumi Yamato, Yuta Matsuoka, Ken-ichi Yamada, Satoshi Miyata, and Junichi Fujii.
    Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice.
    Life Sciences, 95:1-8 (2014) 
  17. Konno T, Otsuki N, Kurahashi T, Kibe N, Tsunoda S, Iuchi Y, and Fujii J.
    Reactive oxygen species exacerbate autoimmune hemolytic anemia in New Zealand black mice.
    Free Radic. Biol. Med. 65:1378-1384 (2013)
  18. Tsunoda S, Kibe N, Kurahashi T, and Fujii J.
    Differential responses of SOD1-deficient mouse embryonic fibroblasts to oxygen concentrations.
    Arch. Biochem. Biophys. 537(1):5-11 (2013)
  19. Kurahashi T, Konno T, Otsuki N, Kwon M, Tsunoda S, Ito J, Fujii J.
    A malfunction in trilyceide transfer from the intracellular lipid pool to apoB in enterocytes of SOD1-deficien mice.

    FEBS Lett. 2012 Dec 14; 586 (24):4289-95
  20. Postnikov VY*, Kurahashi T*, Zhou M and Bustin M.
    The Nucleosome Binding Protein HMGN1 Interacts with PCNA and Facilitates its Binding to Chromatin.

    Mol Cell Biol
    . 2012 May; 32(10), 1844-54. (*contribute equally)
  21. Rochman M, Taher L, Kurahashi T, Cherukuri S, Landsman D, Ovcharenko I and Bustin M.
    Effects of HMGN variants on the cellular transcription profile.

    Nucleic Acid Res
    . 39(10):4076-87, 2011
  22. Kurahashi T , Furusawa T, Ueda T, Bustin M.
    The nucleosome binding protein HMGN3 is expressed in pancreatic alpha-cells andaffects plasma glucagon levels in mice.

    J Cell Biochem
    . 109(1), 49-57, 2010
  23. Ueda T, Furusawa T*, Kurahashi T*, Tessarollo L, Bustin M.
    The nucleosome binding protein HMGN3 modulates the transcription profile of pancreatic beta cells and affects insulin secretion.

    Mol Cell Biol
    . 29(19), 5264-76, 2009 (*contribute equally)
  24. Sawada Y, Katsumata T, Kitamura J, Kawaide H, Nakajima M, Asami T,@Nakaminami K, Kurahashi T, Mitsuhashi W, Inoue Y and Toyomasu T.
    Germination of photoblastic lettuce seeds is regulated via the control of endogenous physiologically active gibberellins content, rather than of gibberellins responsiveness.

    J Exp Bot
    . 59(12), 3383-93, 2008
  25. Jin W, Takagi T, Kanesashi S, Kurahashi T, Nomura T, Harada J, and Ishii S.
    Schnurri-2 Controls BMP-dependent Adipogenesis via Interaction with Smad proteins.

    Developmental Cell
    , 10(4), 461-471, 2006
  26. Kurahashi T, Nomura T, Kanei-Ishii C, Shinkai Y, Ishii S.
    The Wnt-NLK Signaling Pathway Inhibits A-Myb Activity by Inhibiting the Association with Coactivator CBP and Methylating Histone H3.

    Mol Biol Cell
    . 16(10), 4705-4713, 2005
  27. Kanei-Ishii C, Ninomiya-Tsuji J, Tanikawa J, Nomura T, Ishitani T, Kishida S, Kokura K, Kurahashi T, Ichikawa-Iwata E, Kim Y, Matsumoto K, Ishii S.
    Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK.

    Genes Dev
    . 2004 Apr 1; 18(7): 816-29
  28. Michishita E, Kurahashi T, Suzuki T, Fukuda M, Fujii M, Hirano H and Ayusawa D.
    Changes in Nuclear Matrix Proteins During the Senescence-Like Phenomenon Induced by 5-Chlorodeoxyuridine in HeLa Cells.

    Exp. Gerontol.
    37(7), 885-90, 2002
  29.  Michishita E, Matsumura E, Kurahashi T, Suzuki T, Ogino H, Fujii M, and Ayusawa D.
    5-Halogenated Thymidine Analogues Induce a Senescence-like Phenomenon in HeLa Cells.

    Biosci. Biotechnol. Biochem
    .  66(4), 877-9, 2002

y‘àA‘¼z.

  1. Junichi Fujii, Jun-itsu Ito, Xuhong Zhang, and Toshihiro Kurahashi.
    Unveiling the Roles of the Glutathione Redox System In Vivo by Analyzing Genetically Modified Mice.
    J. Clin. Biochem. Nutr. 2011 Sep;49(2), 70-8.
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    “ú–{‰ž—py‘f‹¦‰ïŽ.  46: 1-9 (2012) 
  3. Junichi Fujii, Yoshitaka Ikeda, Toshihiro Kurahashi, Takujiro Homma.  
    Physiological and Pathological Views of Prdx4.
    Free Radic. Biol. Med, 83:373-379 (2015) (invited review)   
  4. Junichi Fujii, Toshihiro Kurahashi, Tasuku Konno, Takujiro Homma, Yoshihito Iuchi.
    Oxidative stress as a potential causal factor for autoimmune hemolytic anemia and systemic lupus erythematosus
    World J Nephrol, 4(2):213-222 (2015) (invited review)  
  5. Toshihiro Kurahashi, Junichi Fujii.
    Roles of Antioxidative Enzymes in Wound Healing.
    J Dev Biol, 3(2);57-70 (2015) (invited review)   
     

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  1. Toshihiro Kurahashi, Jaeyong Lee, Atsunori Nabeshima, Nobuyuki Shirasawa, Sohsuke Yamada, Toshifumi Takao, Junichi Fujii.
    The potential roles of PRDX4 as a thiol oxidase in endoplasmic reticulum.
    17th Biennial Meeting of the Society for Free Radical Research International, Kyoto, March 23-26, 2014 
  2. Toshihiro Kurahashi, Noriyuki Otsuki, Tasuku Konno, Myoungsu Kwon, Satoshi Tsunoda, and Junichi Fujii.
    SOD1 deficiency causes postprandial dyslipidemia due to impaired lipid metabolism in the intestine.
    16th Biennial Meeting of Society for Free Radical Research International, London, UK, Sep, 2012
  3. Kurahashi T, Awada C, Konno T, Otsuki N, Tsunoda S, Zhang X, Ito J, Iuchi Y, Takao T, Fujii J.
    Roles of peroxiredoxin 4 in protein sulfhydryl oxidation.
    5th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia), 8th Conference of Asian Society for Mitochondrial Research and Medicine (ASMRM), Kagoshima, Japan, Sep, 2011
  4. Toshihiro Kurahashi, Tetsuya Ueda, Takashi Furusawa and Michael Bustin.
    Regulation of glucose homeostasis by the nucleosome binding protein HMGN3.
    In: Molecular Basis for Chromatin Structure and Regulation: KEYSTONE SYMPOSIA, USA, Jan, 2010

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E2014 SFRR-Asia Young Investigator Awards at 17th Biennial Meeting of the Society for Free Radical Research
International

E2012 Poster awards at16th Biennial Meeting of the Society for Free Radical Research International, London, Sep 6-9, 2012
E2011 SFRR-Asia Young Investigator Awards at 5th Biennial Meeting of Society for Free Radical Research-Asia
E2010@Fellows Award for Research Excellence 2011 competition@at NIH
E2009@Fellows Award for Research Excellence 2010 competition at NIH
E2008 JSPS Research Fellows in Biomedical and Behavioral Research at NIH


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