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Takujiro HOMMA

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B. S., “Œ‹ž—‰È‘åŠw@–òŠw•” (2007”N3ŒŽj
M. S., “Œ‹ž—‰È‘åŠw‘åŠw‰@@–òŠwŒ¤‹†‰È–òŠwêU CŽm‰Û’öi2009”N3ŒŽj
Ph. D., ’·è‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@V‹»Š´õÇ•a‘Ԑ§ŒäŠwŒnêU@”ŽŽm‰Û’öi2014”N6ŒŽj


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Original Papers

  1. Jaeyong Lee, Eun Sil Kang, Sho Kobayashi, Takujiro Homma, Hideyo Sato, Han Geuk Seo, Junichi Fujii
    The viability of primary hepatocytes is maintained under a low cysteine-glutathione redox state with a marked elevation in ophthalmic acid production.
    Exp Cell Res, 361:178-191 (2017)  
  2. Shinji Hamashima, Takujiro Homma, Sho Kobayashi, Naoki Ishii, Toshihiro Kurahashi, Ren Watanabe, Naoko Kimura, Hideyo Sato, Junichi Fujii.
    Decreased reproductive performance in xCT-knockout male mice.
    Free Radic Res, 51:851-860 (2017)
  3. Jaeyong Lee, Takujiro Homma, Junichi Fujii.
    Mice in the early stage of liver steatosis caused by a high fat diet are resistant to thioacetamide-induced hepatotoxicity and oxidative stress.
    Toxicol Lett, 277:92-103 (2017)  
  4. Eun Sil Kang, Jaeyong Lee, Takujiro Homma, Toshihiro Kurahashi, Sho Kobayashi, Atsunori Nabeshima, Sohsuke Yamada, Han Geuk Seo, Satoshi Miyata, Hideyo Sato, Junichi Fujii
    xCT deficiency aggravates acetaminophen-induced hepatotoxicity under inhibition of the transsulfuration pathway

    Free Radic Res, 51, 80-90 (2017)  DOI: 10.1080/10715762.2017.1282157 
  5. Takaya Shirato, Takujiro Homma, Jaeyong Lee, Toshihiro Kurahashi, Junichi Fujii.
    Oxidative stress caused by a SOD1 deficiency ameliorates thioacetamide-triggered cell death via CYP2E1 inhibition but stimulates liver steatosis.
    Arch Toxicol, 91:1319-1333 (2017) 
  6. Takujiro Homma, Ryusuke Akihara, Satoshi Okano, Mototada Shichiri, Yasukazu Yoshida, Ken-ichi Yamada, Satoshi Miyata, Osamu Nakajima, Junichi Fujii.
    Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a).
    Behav Brain Res, 319:219-224 (2017)
  7. Junitsu  Ito, Naoki  Ishii, Ryusuke  Akihara, Jaeyong  Lee, Toshihiro  Kurahashi, Takujiro  Homma, Ryo  Kawasaki, Junichi Fujii.
    A high fat diet temporarily renders Sod1-deficient mice resistant to an oxidative insult.
    J Nutr Biochem, 40:44-52 (2017)
  8. Takujiro Homma, Junichi Fujii.
    Heat stress promotes the down-regulation of IRE1ƒ¿ in cells: An atypical modulation of the UPR pathway.
    Exp Cell Res, 349:128-138 (2016)
  9. Ryusuke Akihara, Takujiro Homma, Jaeyong Lee, Ken-ichi Yamada, Satoshi Miyata, Junichi Fujii.
    Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress
    Biochem Biophys Res Commun. 478:765-771 (2016)
  10. Toshihiro Kurahashi, Jaeyong Lee, Atsunori Nabeshima, Takujiro Homma, Eun Sil Kang, Yuka Saito, Sohsuke Yamada, Toshiyuki Nakayama, Ken-ichi Yamada, Satoshi Miyata, Junichi Fujii.
    Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy.
    Arch Biochem Biophys, 604:36-46 (2016)
  11. Noriyuki Otsuki, Takujiro Homma, Hiroki Fujiwara, Kenya Kaneko, Yasukazu Hozumi, Mototada Shichiri, Mizuki Takashima, Junitsu Ito, Tasuku Konno, Toshihiro Kurahashi, Yasukazu Yoshida, Kaoru Goto, Satoshi Fujii,Junichi Fujii.
    Trichloroethylene exposure aggravates behavioral abnormalities in mice that are deficient in superoxide dismutase
    Regul Toxicol Pharmacol. 79:83-90 (2016) doi: 10.1016/j.yrtph.2016.05.007.
  12. Noriyuki Otsuki, Tasuku Konno, Toshihiro Kurahashi, Saori Suzuki, Jaeyong Lee, Futoshi Okada, Yoshihito Iuchi, Takujiro Homma, Junichi Fujii,
    The SOD1 transgene expressed in erythroid cells alleviates fatal phenotype in congenic NZB/NZW-F1 mice.
    Free Radic Res, 50(7):793-800 (2016) doi: 10.1080/10715762.2016.1178388.
  13. Toshihiro Kurahashi, Shinji Hamashima, Takaya Shirato, Jaeyong Lee, Takujiro Homma, Eun Sil Kang, Junichi Fujii.
    An SOD1 deficiency enhances lipid droplet accumulation in the fasted mouse liver by aborting lipophagy

    Biochem Biophys Res Commun, 467:866-871 (2015)
  14. Daisuke Ishibashi, Takujiro Homma, Takehiro Nakagaki, Takayuki Fuse, Kazunori Sano, Hanae Takatsuki, Ryuichiro Atarashi, Noriyuki Nishida.
    Strain-Dependent Effect of Macroautophagy on Abnormally Folded Prion Protein Degradation in Infected Neuronal Cells.
    PLoS One. 2015 Sep 14;10(9):e0137958. doi: 10.1371/journal.pone.0137958.
  15. Takujiro Homma, Toshihiro Kurahashi, Jaeyong Lee, Eun Sil Kang and Junichi Fujii
    SOD1 deficiency decreases proteasomal function, leading to the accumulation of ubiquitinated proteins in erythrocytes.
    Arch Biochem Biophys, 583:65-72 (2015) 
  16. Jaeyong Lee, Takujiro Homma, Toshihiro Kurahashi, Eun Sil Kang, andJunichi Fujii.
    Oxidative stress triggers lipid droplet accumulation in primary cultured hepatocytes by activating fatty acid synthesis.

    Biochem Biophys Res Commun
    , 464:229-235 (2015) 
  17. Takujiro Homma, Satoshi Okano, Jaeyong Lee, Junitsu Ito, Noriyuki Otsuki, Toshihiro Kurahashi, Eun Sil Kang, Osamu Nakajima, and Junichi Fujii.
    SOD1 deficiency induces the systemic hyperoxidation of peroxiredoxin in the mouse.
    Biochem Biophys Res Commun
    , 463:1040-1046 (2015) 
  18. Takujiro Homma, Daisuke Ishibashi, Takehiro Nakagaki, Takayuki Fuse, Tsuyoshi Mori, Katsuya Satoh, Ryuichiro Atarashi, and Noriyuki Nishida. Ubiquitin-specific protease 14 modulates degradation of cellular prion protein.
    Sci. Re
    p.
    5:11028 (2015) 
  19. Sho Kobayashi, Mami Sato, Takayuki Kasakoshi, Takumi Tsutsui, Masahiro Sugimoto, Mitsuhiko Osaki, Futoshi Okada, Kiharu Igarashi,Jun Hiratake, Takujiro Homma, Marcus Conrad, Junichi Fujii, Tomoyoshi Soga, Shiro Bannai, and Hideyo Sato.
    Cystathionine is a novel substrate ofcystine/glutamate transporter: implications forimmune function.
    J Biol Chem, 290(14):8778-8788 (2015)
  20. Toshihiro Kurahashi, Myoungsu Kwon, Takujiro Homma, Yuka Saito, Jaeyong Lee, Motoko Takahashi, Ken-ichi Yamada, Satoshi Miyata, and Junichi Fujii.
    Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals.  
    Biochem Biophys Res Commun, 452:136-141 (2014)
  21. Takujiro Homma, Daisuke Ishibashi, Takehiro Nakagaki, Takayuki Fuse, Kazunori Sano, Katsuya Satoh, Ryuichiro Atarashi, Noriyuki Nishida.
    Persistent prion infection disturbs the function of Oct-1, resulting in the down-regulation of murine interferon regulatory factor-3.
    Sci. Rep. 8; 4:6006 (2014)
  22. Takujiro Homma, Daisuke Ishibashi, Takehiro Nakagaki, Katsuya Satoh, Kazunori Sano, Ryuichiro Atarashi, Noriyuki Nishida.
    Increased expression of p62/Sequestosome-1 in prion diseases and its association with pathogenic prion protein.
    Sci Rep. 4:4504. doi:10.1038/ srep04504, 2014.
  23. Mitsutoshi Tsukimoto, Nana Tamaishi, Takujiro Homma, Shuji Kojima.
    Low-dose gamma-ray irradiation induces translocation of Nrf2 into nuclear in mouse macrophage RAW264.7 cells.
    J Radiat Res. 51: 349-353, 2010.
  24. Mitsutoshi Tsukimoto, Takujiro Homma, Yasuhiro Ohshima, Shuji Kojima.
    Involvement of purinergic signaling in cellular response to gamma radiation.
    Radiat Res. 173: 298-309, 2010.
  25. Mitsutoshi Tsukimoto, Takujiro Homma, Yasuko Mutou, Shuji Kojima.
    0.5 Gy gamma radiation suppresses production of TNF-alpha through up-regulation of MKP-1 in mouse macrophage RAW264.7 cells.
    Radiat Res. 171: 219-224, 2009.

y‘àA‘¼z

  1. Takujiro Homma, Junichi Fujii.
    Application of glutathione as anti-oxidative and anti-aging drug.
    Curr Drug Metab, 16:560-571 (2015) (invited review)  
  2. Junichi Fujii, Yoshitaka Ikeda, Toshihiro Kurahashi, Takujiro Homma.  
    Physiological and Pathological Views of Prdx4.

    Free Radic. Biol. Med, 83:373-379 (2015) (invited review)   
  3. Junichi Fujii, Toshihiro Kurahashi, Tasuku Konno, Takujiro Homma, Yoshihito Iuchi.
    Oxidative stress as a potential causal factor for autoimmune hemolytic anemia and systemic lupus erythematosus
    World J Nephrol, 4(2):213-222 (2015) (invited review)  
  4. Takujiro Homma, Junichi Fujii.
    Chapter 2; Indispensable Roles of Superoxide Dismutation in Mammalian Erythrocytes.
    In "
    Superoxide Dismutase (SOD): Sources, Therapeutic Uses and Health Benefits." (Nancy H. Phillips ed.)
    Nova Science Publishers, Inc, 37-57 (2016)
  5. Junichi Fujii, Takujiro Homma, Sho Kobayashi
    Chapter 11: Ascorbic Acid as a Multifunctional Nutrient in Mammals; Our Understanding based on Studies using Genetically Modified Mice.
    In"
    Ascorbic Acid: Properties, Synthesis and Applications"(Emma Parsons, ed.)
    Nova Science Publishers, Inc, 239-265 (2016)  
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    TH LUNG perspectivesAƒƒfƒBƒJƒ‹ƒŒƒrƒ…[ŽÐA 24(4);421-425(2016)@
     

y‘ÛŠw‰ï‚Å‚Ì”­•\z

  1. Takujiro Homma (poster)(SFRR Japan, Young Investigator Award 2017), Naoki Ishii, Sho Kobayashi, and Junichi Fujii.
    [Certificate of Young Investigator Award]
    Heterozygous SOD1 deficiency causes male infertility by triggering autoimmune response in mice with the NZW background.
    The 8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10, December 9-12, 2017, Tokyo, Japan
  2. Takujiro Homma (poster)(SFRR Japan, Young Investigator Award 2016), Takaya Shirato, Jaeyong Lee, Toshihiro Kurahashi, Junichi Fujii.
    [Certificate of Young Investigator Award]
    SOD1-knockout mice are resistant to lethal effects of thioacetamide-induced hepatotoxicity.
    The 23rd Annual Meeting, a joint meeting with the Society for Free Radical Research International (SfRBM/SFRRI 2016), November 16?19, 2016, San Francisco, USA 
  3. Takujiro Homma (poster)(SFRR Japan, Young Investigator Award, 2015), Junichi Fujii.
    [Certificate of Young Investigator Award]

    Intrinsic oxidative stress induces accumulation of ubiquitinated and carbonylated proteins in mouse erythrocytes.
    7th Joint Meeting of the Societies for Free Radical Research Australasia and Japan, Dec 7-10, 2015, Christchurch, New Zealand.

  4. Takujiro Homma, Daisuke Ishibashi, Takehiro Nakagaki, Ryuichiro Atarashi, Noriyuki Nishida. p62/SQSTM1 promotes the sequestration and clearance of pathogenic prion protein. Expanding Prion Horizons. Colorado, Oct, 2013.
  5. Takujiro Homma, Daisuke Ishibashi, Takehiro Nakagaki, Ryuichiro Atarashi, Noriyuki Nishida. p62/SQSTM1 promotes the sequestration and clearance of pathogenic prion protein. Asian Pacific Prion Symposium. Nagasaki, July, 2013.
  6. Takujiro Homma, Daisuke Ishibashi, Ryuichiro Atarashi, Noriyuki Nishida. Increased expression of Sequestosome-1 in prion disease and its association with pathogenic prion protein. Asian Pacific Prion Symposium. Yokohama, July, 2012.
  7. Takujiro Homma, Daisuke Ishibashi, Noriyuki Nishida. Analysis of murine interferon regulatory factor-3 (IRF-3) promoter. International Union of Microbiological Societies (IUMS2011). Sapporo, Sep, 2011.
  8. Takujiro Homma, Keiji Suzuki, Shunichi Yamashita. Analysis of radiation-induced 53BP1 foci in primary human thyrocytes. 2nd Asian Congress of Radiation Research (ACRR 2009). Seoul, May, 2009.
  9. Takujiro Homma, Mitsutoshi Tsukimoto, Yasuko Muto, Yasuhiro Ohshima, Shuji Kojima. Gamma-rayirradiation induce suppression of TNF-a production via up-regulation of mitogen-activated protein kinase phosphatase-1. International Conference on Low Dose Radiation Effects on Human Health and Environmenti6th LOWRADj. Budapest, Oct, 2007.

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EAsian Pacific Prion symposium (APPS) 2013, Best Student Poster Presentation Award
ESFRR Japan Young Investigator Award 2015, at 7th Joint Meeting of the Societies for Free Radical Research Australasia and Japan.
ESFRR Japan Young Investigator Award 2016, at The 23rd Annual Meeting, a Joint Meeting with the Society for Free Radical Research International (SfRBM/SFRRI 2016).
ESFRR Japan Young Investigator Award 2017, at The 8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10.

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